spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

Right arrow Help viewing high resolution images
Right arrow Return to article
(Downloading may take up to 30 seconds.
If the slide opens in your browser, select File -> Save As to save it.)
Click on image to view larger version.


Figure 1


Fig. 1. Model for the role of HPS proteins in melanosome biogenesis. The lysosome-related organelle complexes 1, 2 and 3 (BLOC1-BLOC3) and their subunits are schematically illustrated. Solid arrows indicate cargo proteins being targeted to melanosomes and open arrows illustrate organelle maturation. BLOC1 is implicated in the targeting and fusion of trans-Golgi-network-derived vesicles with early-stage melanosomes; BLOC2 may mediate targeting/docking/fusion of vesicles with more mature melanosomes. Some proteins are transported to melanosomes via early endosomes through AP-3- and BLOC3-dependent processes. Components with identified disease mutations in both humans and mice are indicated by * and those with mouse mutations only by bullet. d, {delta}-subunit; m, µ3-subunit; s, {sigma}3-subunit; b3A, ß3A-subunit.





Right arrow Return to article