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Figure 2


Fig. 2. K1014chim expression in the epidermis of newborn homozygous mutant mice. Sections of mutant (a,b) and wild-type (c,d) skin were stained with the antibodies indicated. (a,b) K5 and K1014chim are co-expressed in the basal layer of the epidermis and the ORS of hair follicles in mutant mice. Note that BrdU-positive nuclei (white arrows in b) are present in K1014chim-positive cell layers, demonstrating that the presence of the K10 end domains is compatible with keratinocyte proliferation. (c,d) In wild-type epidermis, the K10 antibody only stains suprabasal keratinocytes. Note the lack of K10 staining along the ORS of wild-type hair follicles.





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