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Figure 6


Fig. 6. Heterotrimer formation at the plant plasma membrane requires dual lipidation of G{alpha} and G{gamma}. The model shows the formation of Gß{gamma} dimers in the cytosol. The waste-basket symbolizes the breakdown of Gß that occurs in the absence of G{gamma}. Dimerization does not require lipidation. Dual lipidation of G{gamma} targets the Gß{gamma} dimer to the plasma membrane where it can form a heterotrimer with G{alpha} that has been myristoylated in the cytosol and palmitoylated, probably at the plasma membrane. The heterotrimer does not fall apart upon activation of G{alpha} ({alpha}*). The arrows indicate the putative direction(s) of the reactions. Heterodimer and heterotrimer formation might be regulated by de/repalmitoylation cycles.





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