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Fig. 1. Schematic representation of the PDZRN family proteins LNX1 (PDZRN2 or SEMCAP1) and PDZRN3 (LNX3 or SEMCAP3). LNX1 contains an N-terminal RING finger and four PDZ domains, whereas PDZRN3 contains an N-terminal RING finger, two PDZ domains and a consensus-binding motif for class I PDZ domains at its C-terminus. RING-finger and PDZ domains are shown as pink and green boxes, respectively.