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Figure 8


Fig. 8. Model of a protruding lamella illustrating how differential retrograde motion of actin and adhesion proteins can be regulated at two levels in the linkage. The actin (green) and {alpha}-actinin (orange) are always concomitant. Slippage occurs either (A) proximal to {alpha}-actinin through its interaction with one of the components of the linkage complex (shaded molecules) or (B) proximal to the integrins (blue dimers) perhaps at the talin-integrin linkage. (C) Protrusion can occur through polymerization generated forces when both levels of the adhesion complex are engaged.





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