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First published online December 11, 2006

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...tight junctions use nuclear power

The localization of several proteins to both epithelial tight junctions (TJs) and the nucleus suggests that TJs might participate in the regulation of gene expression. On p. 5098, Maria Balda, Karl Matter and co-authors provide compelling evidence that this is indeed the case. They report that two such proteins - the canine Y-box transcription factor ZONAB (DbpA in human cells) and the RNA-processing factor symplekin - cooperate in the regulation of transcription and promote epithelial proliferation. The authors show that ZONAB/DbpA and symplekin, both of which are found at TJs, form a complex in the nucleus of canine kidney and human intestinal cells. Using reporter gene assays they demonstrate that symplekin functionally interacts with ZONAB/DbpA to promote transcriptional repression. Finally, they show that RNAi-induced depletion of symplekin reduces the nuclear accumulation and transcriptional activity of ZONAB/DbpA in human colon adenocarcinoma cells, which inhibits proliferation and reduces expression of the ZONAB/DbpA target gene cyclin D1. Because DbpA is overexpressed in many human tumours, these insights into its regulation could help in the search for anti-cancer drugs.

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Related articles in JCS:

Functional interaction between the ZO-1-interacting transcription factor ZONAB/DbpA and the RNA processing factor symplekin

Emma Kavanagh, Michael Buchert, Anna Tsapara, Armelle Choquet, Maria S. Balda, Frédéric Hollande, and Karl Matter
JCS 2006 119: 5098-5105. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JCS Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?