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First published online December 11, 2006

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Keratin 10 - cancer in the end

Epithelial cells express many keratins, all of which may have specific roles. In the mammalian epidermis, the basal layer (which includes proliferating keratinocytes) expresses keratin 14 (K14), whereas post-mitotic suprabasal keratinocytes express keratin 10 (K10). Because K10 overexpression in the basal layer inhibits keratinocyte proliferation in transgenic mice, it has been proposed that K10 suppresses proliferation in the skin. On p. 5067, Peter Koch and colleagues overturn this idea by showing that expression of K10 end domains (which inhibit cell-cycle progression in vitro) at physiological levels does not inhibit basal keratinocyte proliferation in vivo. The authors have made transgenic mice whose basal keratinocytes express physiological amounts of a chimeric keratin that contains the K14 central domain and the K10 end domains. Skin development is normal in these mice but papillomas form after carcinogen treatment faster than in wild-type mice, partly because apoptosis is suppressed. The authors speculate that K10 normally suppresses cell death in suprabasal keratinocytes to allow them to differentiate, a physiological function missed in experiments in which K10 was overexpressed.

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An unexpected role for keratin 10 end domains in susceptibility to skin cancer

Jiangli Chen, Xing Cheng, Maria Merched-Sauvage, Carlos Caulin, Dennis R. Roop, and Peter J. Koch
JCS 2006 119: 5067-5076. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JCS Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?