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First published online December 11, 2006

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NO limit to muscular dystrophy

Muscular dystrophies are untreatable, sometimes fatal, genetic diseases that are characterized by progressive wasting of skeletal muscle. Stem-cell-based therapies, such as the injection of mesoangioblasts (blood-vessel-associated myogenic stem cells), have usually stimulated only limited muscle repair in animal models of muscular dystrophy. But, on p. 5114, Giulio Cossu, Emilio Clementi and co-authors report that ex-vivo treatment of mesoangioblasts with nitric oxide (NO) donors increases their therapeutic efficacy in the -sarcoglycan-null mouse model of Duchenne muscular dystrophy. NO treatment, they report, enhances the migration of mesoangioblasts to the dystrophic muscles of these mice and helps the mesoangioblasts resist the apoptogenic environment of these muscles and engraft. The authors replicate these beneficial effects of NO in vitro and show that all the effects are GMP-dependent. Finally, they report that NO switches on signalling pathways in the mesoangioblasts that are involved in myogenesis and muscle repair. Thus, the authors conclude, treatment with NO might be a simple way to improve the efficacy of stem-cell therapy for muscle-wasting disorders.

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Ex vivo treatment with nitric oxide increases mesoangioblast therapeutic efficacy in muscular dystrophy

Clara Sciorati, Beatriz G. Galvez, Silvia Brunelli, Enrico Tagliafico, Stefano Ferrari, Giulio Cossu, and Emilio Clementi
JCS 2006 119: 5114-5123. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JCS Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?