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First published online January 27, 2006

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Slk19 helps sisters stick together

When cells divide, multiple checks and controls ensure that their progeny get a complete set of chromosomes. The cohesin complex, for example, prevents premature segregation of duplicated chromosomes by holding sister chromatids together until anaphase. But, as Uttam Surana and co-workers reveal on p. 519, cohesin alone may not be sufficient to prevent chromatids being pulled apart prematurely by the spindle microtubules in budding yeast. They propose that the centromere-associated protein Slk19 acts with cohesin to maintain the centromeric tensile strength needed to resist the poleward pull of the spindle. They show that, in Slk19-deficient cells, the separating nuclei migrate prematurely and the chromatin mass undergoes a partial division that is accompanied by the loss of centromeric elasticity. Slk19, they report, is physically associated with the cohesin Scc1, and this association is needed for the efficient cleavage of Slk19 by separase, which initiates chromatid separation by cleaving Scc1. The authors envisage that centromere-associated proteins that serve a similar function to Slk19 may exist in other organisms.

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Related articles in JCS:

Deficiency of centromere-associated protein Slk19 causes premature nuclear migration and loss of centromeric elasticity

Tao Zhang, Hong Hwa Lim, Chee Seng Cheng, and Uttam Surana
JCS 2006 119: 519-531. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JCS Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?