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First published online January 27, 2006

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Signalling platforms from the vaults

Cells from many organisms contain hollow ribonucleoprotein particles called vaults. Although these conserved structures have been implicated in several cellular processes, their exact function remains a mystery. One possible function is as interaction platforms for signalling cascades, since components of the phosphoinositide 3-kinase and MAP-kinase signalling pathways associate with vaults. On p. 459 Walter Berger's team strengthens the evidence for this potential function by reporting that the major vault protein (MVP) responds to and interferes with interferon (IFN-) signalling. The authors show that IFN- upregulates MVP transcription and translation and identify an MVP promoter element that interacts with STAT1, a transcription factor downstream of IFN- receptors. Mutation of this element reduces both basal and IFN--induced MVP transcription. In addition, the authors report that MVP overexpression downregulates STAT1-dependent gene expression. Because IFN--mediated JAK/STAT signals protect against tumour development by inhibiting proliferation and activating apoptosis, these data may thus explain why MVP is upregulated in many tumours.

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Related articles in JCS:

The major vault protein is responsive to and interferes with interferon--mediated STAT1 signals

Elisabeth Steiner, Klaus Holzmann, Christine Pirker, Leonilla Elbling, Michael Micksche, Hedwig Sutterlüty, and Walter Berger
JCS 2006 119: 459-469. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JCS Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?