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Figure 1


Fig. 1. Distribution of integrins and tetraspanins on human eggs. Intact (A-E) or zona pellucida free (F-O) human eggs were labelled with anti-{alpha}6 integrin (A,F,I,L), anti-ß1 integrin (B,G), anti-CD151 (C,J), anti-CD81 (D,M) and anti-CD9 (E,O), mAbs. A merged image (H) of {alpha}6 (F) and ß1 (G) shows that the subunits co-localize on the plasma membrane. Merged images (K and N) of {alpha}6 (I and L) with CD151 (J) or CD81 (M), respectively, show that the integrin {alpha}6ß1 co-localizes with these two tetraspanins on the oolemma. All these molecules are evenly distributed on ZP-intact eggs. On ZP free eggs, ß1 integrin subunit, CD81 and CD151 tetraspanins co-localize with {alpha}6 integrin subunit. CD9 remained evenly distributed. Bar, 50 µm.





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