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Figure 4


Fig. 4. JAM-A-induced HUVEC migration on vitronectin is integrin {alpha}vß3 specific. HUVECs stably transfected with JAM-A or mock transfected were pre-treated with various concentrations of antibodies or inhibitors as indicated. Cell migration assays on vitronectin or fibronectin were performed as described in the Materials and Methods. (A) Pre-treatment with anti-{alpha}vß3 antibody (*P<0.05), (B) pre-treatment with anti-{alpha}vß5 antibody, (C) pre-treatment with XT199 RGD-based antagonist specific to integrin, (D) same as in (C) on fibronectin.





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