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Fig. 6. The dynamics of ATP binding and hydrolysis by the myosin constructs were analyzed in terms of the models shown in Schemes 1-3, where M refers to myosin head fragment, A to actin, and T, D and Pi to ATP, ADP and phosphate, respectively. In these schemes, a notation is used that distinguishes between the constants in the presence and absence of actin by using bold (K+1, K1) versus italic type (k+1, K1); subscript A and D refer to actin (KA) and ADP (KD), respectively.