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Fig. 7. Subnuclear localization of coilin, SMN and TMG of snRNA in SMA-derived fibroblasts. (A) Immortalized control and type I SMA patient fibroblasts were co-stained for SMN (green) and the snRNP marker TMG (red). SMN foci in control cells colocalized with snRNPs, as shown in the insert. By contrast, SMN foci detected in SMA cells were never found snRNP-positive (see insert). It should be noticed that coarse TMG labelling in the nucleoplasm of SMA cells was also observed in controls. (B) Primary fibroblasts derived from control and type I, II and III SMA were immunostained for SMN (green) and coilin (red). (C) Primary fibroblasts derived from control and type I, II and III SMA were immunostained for SMN (green) and TMG (red). Inserts show staining for SMN (left) and coilin or TMG (middle), and the merged image (right). Bars, 3 µm.
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