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Figure 5


Fig. 5. Loss of Par-1 causes a neurogenic phenotype in late stage embryos. Embryos stained for neuron-specific Neuroglian at stage 15; whole embryos (left panels) and representative segments of peripheral nerves (right panels). (A,B) Wild-type embryos develop highly organized central and peripheral nervous systems with characteristic numbers of neurons. (C,D) par-1(RNAi) embryos and (E,F) N55e11 mutants display hyperplasia of central and peripheral nervous systems. (G,H) scrib(RNAi) embryos and (I,J) shg2, (K,L) bazXI106 and (M,N) crb11A2 mutants all show defects in nervous system development, but have negligible to minor neural hyperplasia.





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