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Figure 1


Fig. 1. In rats, incisional wound healing is accelerated and inflammatory cell influx attenuated by 5{alpha}-reductase inhibition. (A,C) Day-2 and -6 wound sections were subjected to histological analysis and quantification. Wound areas at day 2 post wounding were reduced in wounds of castrated (CSX) animals and those treated with MK-434 (n=5-7 per group). Arrows indicate the wound margins. (B,D) Numbers of ED1-positive macrophages (studied immunohistochemically, quantified and indicated by arrows) in day-2 and -6 wounds of castrated animals were reduced as they were in day-2-wounds of animals treated with MK-434. (B,E) Numbers of His48-immunoreactive granulocytes (arrows) were significantly reduced both in day-2-wounds of castrated animals and those treated with MK-434. Bars, 500 µm (A) or 50 µm (B). Data represent mean ± s.d. *P<0.05; **P<0.01.





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