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Figure 4


Fig. 4. Numbers of macrophages, neutrophils and TNF-{alpha}-positive cells in wounds of Smad3-/- mice are not affected by castration. Day 3 wound sections were analysed immunohistochemically to quantify inflammatory cells, and IL-6- and TNF-{alpha}-immunoreactive cell numbers. (A) Numbers of macrophages were significantly reduced in day-3-wounds of castrated wild-type mice but were not affected in day-3-wounds of Smad3-/- animals (n=4-5 per treatment group). (B) The population of neutrophils was similarly depleted in wounds of castrated wild-type mice but not of Smad3-/- animals. (C) Numbers of TNF-{alpha}-positive cells were decreased in day-3-wounds of castrated wild-type animals but were not affected in day-3-wounds of castrated Smad3-/- mice. (D) Numbers of TGF-ß1-immunoreactive inflammatory cells were increased solely in wounds of castrated wild-type mice. Arrows indicate immunoreactive cells; dashed lines in D indicate the dermal-epidermal boundary. Bars, 20 µm. Data represent mean ± s.d. *P<0.05; **P<0.01. EP, epidermis.





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