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Fig. 4. The source of the intracellular Ca2+ signal induced by testosterone. Cells were stimulated with testosterone in the presence of intracellular Ca2+ release inhibitors. (A) Pre-incubation of cells with nifedipine did not alter the Ca2+ response. (B) In Ca2+-free medium (0.5 mM EGTA) only the first peak was produced and no oscillations were observed. (C) Incubation with 1 mM Gd3+ (a nonspecific Ca2+ channel blocker) mimicked the response seen in Ca2+-free medium. (D) Ryanodine had no effect, whereas U73122 and 2APB abolished the Ca2+ signal (E,F).
