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Figure 7


Fig. 7. Model for differential responses of mouse and human EBs to TGFß. The schematic shows the alternative lineages leading to the hematopoietic and endothelial lineages of the human and mouse yolk sac. The key species difference is highlighted as a bold connecting arrow to the yolk-sac mesoderm (solid for human, dashed for mouse). TGFß inhibition of hypoblast formation would thus affect descendants of the hypoblast in human but not mouse. Cell types downregulated by TGFß in both species are indicated as solid gray oblongs, those down-regulated by TGFß in human but not in mouse are indicated as hatched gray oblongs.





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