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Figure 10


Fig. 10. MT1-MMP is essential for matrix degradation. (A) Inhibition of MT1-MMP expression by siRNA MT1-MMP was visualised by western blot. (B) siRNA MT1-MMP blocked MMP2 activation. Cells lysates from HUVECls treated with PMA in the presence or absence of siRNA MT1-MMP, were analysed by gelatin zymography. (C) MT1-MMP-expression knock-down increases the number of cells with podosomes. HUVECs were treated with PMA in the presence or absence of siRNA MT1-MMP. Cells showing podosomes were counted and the data are presented as percentage of the total population. Error bars represent the mean ± s.d. of two independent experiments.





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