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Figure 3


Fig. 3. Sequence features and disease-associated amino acid changes in caveolins-1 (Cav1) and -3 (Cav3). Some key amino acids and features of caveolin-1 and caveolin-3 are shown in relation to defined domains of caveolin-1 and caveolin-3. Numbers above the lines indicate amino acid number in mammalian caveolins. Palmitoylation sites (Palm) in caveolin-1 are indicated in green (potential sites in caveolin-3 are not shown), phosphorylation sites (P) are shown in red, and the starting methionine (M33) of caveolin-1ß is shown in black. Caveolin-3 residues are numbered assuming a single methionine residue at the N-terminus. Disease-associated amino acid substitutions in caveolin-1 and caveolin-3 are shown in blue. Abbreviations: RMD, rippling muscle disease; DM, distal myopathy; FHCK, familial hyperCKaemia; SHCK, spontaneous hyperCKaemia; MYO, myopathy; LGMD1C, limb girdle muscular dystrophy 1C; BC, breast cancer.





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