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Figure 4


Fig. 4. Topology model of caveolin-1. Helical and buried regions have been predicted from primary structure. The model assumes that charged groups (green) have access to the membrane surface and tryptophan residues (W) are hydrogen bonded. Note that tryptophan residues stay within one helical turn of either the cytosolic (W85, W98, W128) or the exterior (W115) membrane interface. Aromatic residues tend to stay together (black numbers indicate their position in rotational degrees relative to the first aromatic residue of each segment). Segment 80-95 qualifies as an in-plane amphipathic membrane anchor and might compensate for the effect of segment 95-110 being shorter than segment 110-130. Aromatic residues are depicted in yellow, known surface accessible residues in red, and the palmitoyl moieties are to scale. (Numbers correspond to murine caveolin-1.)





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