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Figure 5


Fig. 5. Ab perturbation of Sec8 function significantly influences OL morphology. Mature OLs in culture were microinjected with dextran (red) and either anti-Sec8 Ab or IgG; 60 minutes after injection, cells were fixed and labeled with anti-MBP Ab (green). Cells were analyzed into three groups: (a) group 1: cells with fragmented processes and/or membranes; (b) group 2: cells with small areas and short processes (low and medium morphological complexity) and (c) group 3: cells with high complexity. Cells in each group are shown as percentage of the total dextran-positive injected cells (173 cells injected with anti-Sec8 Ab; 112 cells injected with IgG; n=3 independent experiments; P<0.003). Bars, 10 µm.





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