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Figure 8


Fig. 8. CASK is detectable in MBP-positive OLs and myelinated axons in cocultures and in vivo. (A) OL-neuronal cocultures were immunolabeled with anti-MBP Ab (red) and anti-CASK Ab (green), and analyzed by confocal microscopy followed by the 3D reconstruction of Z-stacks of images. Arrows indicate MBP-positive OLs and arrowheads indicate myelinated fibers. (B,C) CASK (green) is detectable in (B) cells with a chain-like pattern, suggestive of intrafascicular OLs (rat brain) and (C) MBP-positive myelinated fibers in longitudinal or cross-sections (mouse spinal cord). The arrow in (C) indicates a CASK-positive cluster localized in an MBP-positive myelinated fiber in cross-section. Bars, 10 µm (A-C), 5 µm (C).





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