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Figure 5


Fig. 5. Comparison of Ca2+- and cAMP-interplay in the presence of different AC8 activators. Parallel experiments of cytosolic Ca2+ changes (black trace) and Epac-1 FRET ratios (coloured traces) after Tg-induced store-depletion at 60 seconds and subsequent imposed 2-minute-long Ca2+ oscillations. (A) Modest cAMP oscillations in a single cell in response to Ca2+ changes without adenylyl cyclase activator. (B-D) CCE-evoked cAMP oscillations following addition of (B) 10 nM PGE1 at 310 seconds, (C) 10 nM isoprenaline at 310 seconds, (D) 10 nM forskolin at 310 seconds.





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