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Fig. 1. Sequence alignment of human Sec31B-F. The derived aa sequence of the human Sec31B-F (GenBank accession number AF274863) aligned with human Sec31A (Tang et al., 2000) and Sec31p (Salama et al., 1997) by the program MegAlignTM (DNAStar) using the J. Hein algorithm. Identical residues are shaded. Sec31B shares 47.3% and 18.8% identity to human Sec31A and yeast Sec31p respectively. The bar indicates the extent of Sec31B-T, the truncated isoform derived from utilization of exon 13. This isoform retains the WD-repeat region found in the N-terminal half of the protein, responsible for Sec13 binding, but lacks the C-terminal region responsible for Sec23-Sec24 binding (Shaywitz et al., 1997).
