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Figure 10


Fig. 10. Scheme of the proposed signal transduction cascade activated by ROS and hypoxia. Either hypoxia (initiating elevated ROS generation) or exogenous addition of ROS induces phosphorylation of gp130 and initiates a feed-forward cycle of NADPH oxidase activity and expression. ROS generated by NADPH oxidase act as signalling molecules within the CT-1/gp130 signalling cascade which finally results in HIF-1 upregulation and stimulation of CT-1 expression.





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