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Figure 8


Fig. 8. Upregulation of CT-1 mediated by menadione and CoCl2 is inhibited by the HIF-1{alpha} inhibitor 2-ME (3 µM). Embryoid bodies were treated at day 4 of cell culture with either menadione (20 µM) or CoCl2 in the presence of 2-ME. CT-1 protein expression was assessed after 24 hours by semiquantitative immunohistochemistry. *P<0.05, significantly different from levels in the untreated control; #P<0.05, significantly different to levels before addition of 2-ME.





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