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Figure 9


Fig. 9. (A) Cardiac cell differentiation in wild-type (wt) and HIF-1{alpha}-/- ES cells. Expression of CT-1 during differentiation (B) and upon incubation with menadione (20 µM) and CoCl2 (50 µM) (C,D). In HIF-1{alpha}-/- ES cells cardiomyogenesis was completely absent as evaluated by counting the number of spontaneously contracting embryoid bodies (A). Furthermore, no upregulation of CT-1 mRNA was observed in HIF-1{alpha}-/- compared with the wild type (B). Menadione as well as CoCl2 failed to upregulate CT-1 mRNA (C) and protein (D) in HIF-1{alpha}-/- cells. *P<0.05, significantly different to levels in wild-type embryoid bodies.





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