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Figure 10


Fig. 10. Models for dual Fmi functions in dendritic morphogenesis. Diagrams show models of putative Fmi function at two distinct phases of dendritic morphogenesis. (A) Branch outgrowth in the embryo. For simplicity, only ddaD and ddaE are illustrated. Fmi (indigo bars) that is expressed in neurons binds to an unknown ligand (red diamonds). Fmi-ligand binding (yellow star) elicits inhibitory signaling against branch extension. A dendritic branch that responded to this signal is indicated as a green bar (right panel). In this illustration, a source of this ligand is hypothesized to be located dorsally in non-neural cells. The secreted ligand is postulated to not propagate very far, but to stay close to its source. (B) Inhibitory communication at dendro-dendritic interfaces in larvae. Class IV da (ddaC) neurons extend dendritic terminals that encounter terminals of contralateral counterparts along the dorsal midline. Signaling occurs at the interfaces, triggerd by Fmi-Fmi homophilic interaction (magenta star). In turn, this triggers local signal transduction of heteroneuronal avoidance (green dendritic branches at the right).





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