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Fig. 5. The five canonical EF-hand motifs in RSP7. An asterisk indicates a precise match to the Ca2+-binding loop consensus sequence D-x-[DNS]-{ILVFYW}-[DENSTG]-[DNQGHRK]-{GP}-[LIVMC]-[DENQSTAGC]-x(2)-[DE]-[LIVMFYW], where x = any amino acid, [] = either/or, and {} = any amino acid except those in brackets (PROSITE accession number PS00018). The Ca2+ ligands that contribute oxygen atoms are denoted as X, Y, Z, -Y, -X and -Z.