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Figure 6


Fig. 6. Model for radial spoke structure. The diagram illustrates the probable locations of the RSPs (A) and their molecular modules (B) relative to a central pair microtubule (right) and an inner dynein arm on an outer doublet microtubule (left). LC8, dynein light chain 8; MN, MORN domain Ox/Re, aldo-keto reductase domain. The locations of the RSPs are based on studies of mutants (Huang et al., 1981; Patel-King et al., 2004; Yang et al., 2005) and chemical dissection of the spoke (Piperno et al., 1981); RSPs 18 and 19 are not included because of insufficient experimental evidence to locate them within the radial spoke. The stoichiometry of subunits is speculative but is based on the homodimerization of RSPs 3, 16 and 22 (Benashski et al., 1997; Yang et al., 2005) (W.S. and P.Y., unpublished data), the presence of homodimerization domains in RSPs 2, 7 and 11, and other data discussed in Yang et al. (Yang et al., 2004).





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