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Figure 9


Fig. 9. Drosophila Cad99C is closely related to human PCDH15. (A) Drosophila melanogaster (Dm) Cad99C, Anopheles gambiae (Ag) Cad99C, Mus musculus (Mm) Pcdh15 and Homo sapiens (Hs) PCDH15 share a similar protein domain organization. They are single-span transmembrane (TM) proteins containing a signal peptide (Sp) and 11 cadherin repeats in their extracellular regions. The cytoplasmic region has a conserved PDZ domain-binding site (PDZ-BS). The available Anopheles Cad99C sequence is incomplete at its N-terminus. (B) Conservation of a C-terminal PDZ domain-binding site between the four proteins. The cytoplasmic regions of Drosophila and Anopheles Cad99C, and mouse Pcdh15 and human PCDH15 contain conserved C-terminal class I PDZ domain-binding sites (underlined) with the consensus sequence (S/T)XL (Sheng and Sala, 2001). (C) Phylogenetic tree built with the UPGMA method. Dm Cad99C, Ag Cad99C, Mm Pcdh15 and Hs PCDH15 segregate into the same clade (box), indicating that Cad99C and PCDH15 share a common evolutionary history and are more related to each other than to any other of the cadherins considered. The non-classical cadherins Dm and Ag Cad88C appear to be related to Hs cadherin 23 (CDH23) and Mm Cdh23; like PCDH15, CDH23 is etiologically associated with Usher syndrome type I.





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