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Figure 2


Fig. 2. Antagonistic interactions between oppositely localized PAR-aPKC system components that lead to the establishment of complementary membrane domains. (A) C. elegans zygote. (B) Drosophila/mammalian epithelial cells. In epithelial cells, the involvement of additional evolutionarily conserved polarity proteins (Crb/Pals1/PATJ and Lgl/Scrib/Dlg) has also been demonstrated. The components of the PAR-aPKC system are shown in black boxes. Red indicates anterior or apical polarity proteins, whereas blue indicates posterior or basolateral polarity proteins. Green indicates proteins that do not show clear asymmetric localization. Red- and blue-colored boxes enclose proteins categorized into functional groups whose localizations are mutually dependent (the requirement of PATJ for the localization of Crb and Sdt/Pals1 has been shown only in MDCK cells not in Drosophila) (Pielage et al., 2003; Shin et al., 2005). The role of PAR-4 in these interactions has not been well clarified, although its close functional relationship with PAR-1 has been demonstrated in both types of cell (see text).





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