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Figure 3


Fig. 3. The protein-protein interaction network involving polarity proteins in mammalian epithelial cells. The key shows the protein domains involved. Black arrows indicate direct physical interactions, whereas orange dotted arrows indicate phosphorylation. Putative interactions suggested from the data obtained using Drosophila epithelia are indicated by gray dotted arrows with question marks. The involvement of PAR-5/14-3-3 is not shown in this figure to avoid complication, although PAR-5/14-3-3 has been demonstrated to interact with PAR-1b and PAR-3. PAR-1b is suggested to phosphorylate microtubule-associated proteins (MAPs) and thereby affect microtubule stability (Drewes et al., 1997; Cohen et al., 2004). AJ, adherens junction; TJ, tight junction.





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