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Figure 2


Fig. 2. Model for the roles of Pex3p and Pex19p in the insertion of proteins into the peroxisomal membrane. According to the model, the insertion of Pex3p into the ER membrane and the subsequent recruitment of Pex19p to the membrane leads to the formation of a pre-peroxisomal organelle. At this stage, cytosolic Pex19p can also engage in peroxisomal membrane protein (PMP) import by binding peroxisomal membrane proteins and targeting these to the pre-peroxisomal membrane. By an unknown process, the PMP cargo is released from the membrane-associated Pex19p and is inserted into the membrane. Once PMP insertion is complete, matrix proteins begin to be imported, resulting in the functional maturation of the pre-peroxisome into a peroxisome.





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