spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

Right arrow Help viewing high resolution images
Right arrow Return to article
(Downloading may take up to 30 seconds.
If the slide opens in your browser, select File -> Save As to save it.)
Click on image to view larger version.


Figure 7


Fig. 7. PTP1B structural requirements for formation of cell-matrix adhesion site puncta. PTP1B null cells were transfected with GFP-PTP1B DA/PA (A,B), GFP-PTP1B DA/YF (C,D) and GFP-PTP1B DA/t280 (E,F) and fixed 20 hours later. Cells stained with anti-FAK (A,C) or anti-vinculin (B,D,F), followed by secondary antibodies conjugated with Alexa Fluor 568. Note that PTP1B DA/PA and PTP1B DA/YF form typical punctate structures (A-D, arrows) whereas PTP1B DA/t280 has lost the punctate distribution and appears throughout the entire area of the cell-matrix adhesion foci (arrows in E and F). Bar, 20 µm.





Right arrow Return to article