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Fig. 5. Increased number of L1ir synaptic and orphan boutons in NP^-/- mice. (A) Typical distribution of L1ir synapses (dots) in NP^+/+ (left) and NP^-/- (right) mice in the CA1 subfield. L1ir synaptic boutons are plotted on a montage of 25 low-power (x6000) electron micrographs of stratum pyramidale (str.pyr.), stratum radiatum (str.rad.) and stratum lacunosum moleculare (lac-mol.). The stratum radiatum (str. rad.) was divided into three regions, proximal (prox.), middle (mid.) and distal (dist.), according to the distance from CA1 soma. (B) The number of asymmetrical L1ir synapses was counted in NP^+/+ (open bars) and NP^-/- (closed bars) mice. The left graph shows the number of L1ir synapses in a fixed area (13.0x219.6 µm) of the CA1 stratum radiatum, and the right graph shows the number in each region according to the distance from CA1 soma in a fixed area (13.0x73.2 µm). The mean number of L1ir synapses was significantly higher in NP^-/- mice. ^*P<0.05. (C) Total number of asymmetrical synapses containing L1ir and L1ir-negative synapses was counted in NP^+/+ (open bars) and NP^-/- (closed bars) mice. The left graph shows the number of synapses in the stratum radiatum in a fixed area (13.0x219.6 µm), and the right shows the number in each region depending on the distance from the CA1 soma in a fixed area (13.0x73.2 µm). The mean number of total synapses was significantly lower in the proximal region of NP^-/- mice. ^*P<0.05. (D) The mean number of L1ir orphan boutons was significantly higher in NP^-/- (closed bars) mice than NP^+/+ (open bars) mice in the proximal region in a fixed area (13.0x16.5 µm). ^*P<0.05; ^**P<0.01.

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