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Fig. 8. Diagrammatic model of synapse conversion. Formation of synapses is divided into two phases, an early phase where L1ir orphan boutons make contact with small spines (a) and a late phase where small synapses containing L1 grow into large synapses lacking L1 (b). Neuropsin is considered to be involved in both phases. Presynaptic boutons are shown in pale green, spines in pale blue, PSD is bright blue, L1 in red, and synaptic vesicles as circles.