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Figure 6


Fig. 6. Effects of mutation of Sp1 and CTF sites in the OLIG2-responsive region of the p27Kip1 gene promoter on transcriptional activity. (A) Schematic representation of p27PF-based luciferase reporter plasmids containing point mutations in the Sp1-1, Sp1-2 or CTF sites (underlined). (B) Luciferase activities of U12-1 cells transfected with the indicated reporter plasmids and cultured in Tet-on or Tet-off medium. Firefly luciferase activity was normalized using that of pRL-TK plasmid. Data are means ± s.d. of values from at least three independent experiments. *P<0.05, **P<0.01 (Student's t-test).





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