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Figure 6


Fig. 6. The conserved ARE sequence affects Msi1 mRNA stability in vitro. (A) Decay assay of µmsi1ARE+ and µmsi1AS radio-labeled transcripts at different time points. The A60 labels represent the initial µmsi1ARE+ and µmsi1AS transcripts with 60 adenines in the polyA tail, whereas the A0 labels represent the corresponding deadenylated transcripts. (B) The deadenylation rate of the µmsi1ARE+ RNA changed after the addition of 0.75 µg of the HuD protein, with a decay pattern similar to that of the µmsi1AS transcript. The deadenylation/degradation profiles were highly reproducible (compare the µmsi1ARE+ decay in A and B).





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