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Figure 4


Fig. 4. APC slows down ß-catenin in the cytoplasm and slightly decelerates ß-catenin nucleo-cytoplasmic shuttling. (A) Live cell images of mYFP-ß-cateninS45A and co-expressed mCFP-APC. The tip of a protrusion where APC and ß-catenin co-accumulate is indicated by an arrow. Bar, 10 µm. (B) Compartment bleach analysis of mYFP-ß-cateninS45A shuttling in the absence or presence of mCFP-APC. (C) Cytoplasmic point bleach analysis of mYFP-ß-cateninS45A in the absence or presence of mCFP-APC. mYFP-APC mobility was determined in a separate experiment. Note the low mobility of APC and ß-cateninS45A at the tips of cellular protrusions (tips) as compared to the cell body (cb). The cartoons in B and C designate compartment bleaches and point bleaches, respectively.





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