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First published online March 22, 2006

Journal of Cell Science 119, 703e (2006)
© The Company of Biologists Limited
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In this issue

SNAREd by phospholipase D


Figure 1

Vesicle fusion is important for many cellular processes, including membrane trafficking, endo/exocytosis and yeast sporulation. During sporulation, vesicles gather on the spindle pole bodies and fuse to form prospore membranes around the daughter nuclei. Aaron Neiman and co-workers now reveal that Spo14p - the major yeast phospholipase D (PLD) - and its product phosphatidic acid (PA) promote the fusion process (see p. 1406). The authors show that, in cells that lack Spo14p or cells that express catalytically inactive Spo14p, prospore precursor vesicles accumulate on the spindle pole bodies but fail to fuse. Similar accumulations occur in cells that lack the SNARE protein Sso1p or the partially redundant SNAREs Sec9p and Spo20p. The authors show that PA recruits Spo20p to precursor vesicles but that PA-independent targeting of Spo20p to these vesicles does not restore prospore membrane formation in Spo14p-deficient cells. They conclude that PA is not only important for SNARE targeting but also has other roles in the fusion process. Since PLD has been implicated in regulated exocytosis in mammalian cells, it may play similar roles in membrane fusion in higher organisms.


Related articles in JCS:

Phospholipase D and the SNARE Sso1p are necessary for vesicle fusion during sporulation in yeast
Hideki Nakanishi, Masayo Morishita, Cindi L. Schwartz, Alison Coluccio, JoAnne Engebrecht, and Aaron M. Neiman
JCS 2006 119: 1406-1415. [Abstract] [Full Text]  




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