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First published online March 22, 2006

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PTP route to mature attachment

Adhesion of cells to the extracellular matrix is important for tissue formation, transmembrane signal transduction and cell migration. How cell-matrix adhesion sites form is largely unknown, however. Carlos Arregui and colleagues now throw new light on the process by implicating protein tyrosine phosphatase 1B (PTP1B) in the maturation and stabilization of these adhesion sites (see p. 1233). They use GFP-labelled PTP1B D181A, a substrate-trapping mutant of PTP1B that forms stable enzyme-substrate complexes, to visualize the subcellular localization of PTP1B. The authors' results indicate that PTP1B is associated with the external face of the ER and punctate structures (foci) at the distal tips of immature cell-matrix adhesion sites. Intriguingly, they also suggest that PTP1B is targeted to these structures by ER tubules that are projected towards cell-matrix adhesion sites by microtubules. In addition, Arregui and colleagues observe that maturation of the foci is impaired in PTP1B-null cells. PTP1B could therefore be required for adhesion site maturation and, consequently, the stabilization of lamellae during cell migration.

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ER-bound PTP1B is targeted to newly forming cell-matrix adhesions

Mariana V. Hernández, Maria G. Davies Sala, Janne Balsamo, Jack Lilien, and Carlos O. Arregui
JCS 2006 119: 1233-1243. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JCS Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?