spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

Right arrow Help viewing high resolution images
Right arrow Return to article
(Downloading may take up to 30 seconds.
If the slide opens in your browser, select File -> Save As to save it.)
Click on image to view larger version.


Figure 3


Fig. 3. Rac1/Cdc42-stimulated PAK activation requires GIT-PIX oligomers. Activated Rac1 and Cdc42 interact with inactive PAK, causing a conformational change that allows it to bind to GIT-PIX oligomers through a direct interaction with PIX. High local concentrations of PAK permit autophosphorylation (P), stimulating the kinase activity of PAK and its subsequent disassociation from the GIT-PIX oligomers.





Right arrow Return to article