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Figure 3


Fig. 3. Split decomposition tree (upper panel) and principal component analysis (PCA) (lower panel) constructed using AP-PCR data of clones and subclones compared with the respective parental cell. Parental cell lines were represented as a single and common point (marked P) defined by a vector (0,0,0,...). Each AP-PCR band corresponds to a component of the vector and the values indicate loss (–1), gain (+1), or no change (0) in the clone in regard to the fingerprint of the parental cell. Clones of the SW480 cell line are labeled `S', clones of LoVo are labeled `L' and clones of HCT116 are labeled `H'. Tree and space arrangement revealed the differential nature of genetic alterations characterizing the divergence in the clones derived from each cell line. In PCA analysis, the spikes are traced to the centroid point of the clones for each cell line.





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