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Fig. 2. Soleus muscle is dramatically affected at an early age in Dp116/mdx^4cv transgenic mice. Complete cross sections of hematoxylin- and eosin-stained soleus muscles from Dp116/mdx^4cv (a',b') and mdx^4cv (a,b) mice at both 3 weeks (a,a') and 4 weeks (b,b') of age are shown. At 3 weeks the mdx^4cv muscle has small areas of degeneration but minimal numbers of fibers with central nuclei. At this age, Dp116 transgenic muscle shows extensive degeneration and inflammation with clusters of regenerated fibers containing central nuclei (arrow). At 4 weeks the mdx^4cv muscle has many successfully regenerated fibers (arrow) and large areas of normal tissue. By contrast, the transgenic muscle at 4 weeks has little normal muscle tissue remaining. Bar, 500 µm.

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