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Figure 6


Fig. 6. Expression of dystrophin-associated proteins is restored in Dp116/mdx4cv transgenic muscle. (A) Immunofluorescence staining of quadriceps muscles with antibodies specific for ß-dystroglycan, {alpha}-sarcoglycan, ß-sarcoglycan, {gamma}-sarcoglycan, {alpha}-dystrobrevin 2, and {alpha}1-syntrophin. Bar, 100 µm. (B) Western blots from KCl-washed microsomes using antibodies against the dystrophin C-terminus (Dys-2), ß-dystroglycan, ß-sarcoglycan, {gamma}-sarcoglycan, {alpha}-dystrobrevin 2, and {alpha}1-syntrophin. An identical gel stained in parallel with Coomassie Blue is shown as a loading control. c, C57Bl/6; m, mdx4cv; tg, Dp116/mdx4cv.





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