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Figure 7


Fig. 7. The calcineurin inhibitor cain/cabin1 blocks the nuclear translocation of NFATc1-GFP. (A,B) Soleus muscles co-transfected with plasmids coding for NFATc1-GFP and myc-tagged cain. (C,D) TA muscles co-transfected with plasmids coding for NFATc1-GFP and myc-tagged cain and electrostimulated for 2 hours with a 20 Hz impulse pattern. Serial sections were either stained with anti-myc (A,C,E,G) or examined for GFP fluorescence (B,D,F,H). (E-H) Occasional fibers in electrostimulated TA muscles that do not express cain (asterisks) maintain a nuclear localization of NFATc1, whereas neighboring fibers that do express cain show a cytoplasmic localization of NFATc1-GFP. Bar, 30 µm.





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