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Figure 7


Fig. 7. (A-C) Specific inhibitors of the NO-cGMP pathway (B) affect nuclear AUF1 levels and (A) abolish the effects of NMDA on nuclear AUF1 levels and on (C) the accumulation of {alpha}2 mRNA. Cells were incubated with the indicated compounds alone or in combination with 100 µM NMDA for 24 hours (ODQ and KT5823 were added 30-60 minutes before NMDA). Subsequently, proteins or RNA were extracted and processed as described in the Materials and Methods. (KT5823, 1 µM; MK-801, 5 µM; ODQ, 10 µM; and Sp-8-Br-PET-cGMPS, 50 µM). The results are the mean ± s.e.m. of four experiments. *P<0.001, significant difference from control values.





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